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MEDICAL ANIMATION TRANSCRIPT: The brain's cognitive functions include memory, which is the process of information retention and retrieval. Memories form in the hippocampus, which consists of information-processing cells called neurons. Each neuron receives chemical messages from other neurons via dendrites, then converts the message to an electrical charge called an action potential. In the space between them, neurons release stimulatory chemicals called neurotransmitters, which bind with receptors on the receiving cell and transfer information. Alzheimer's disease is a gradual, degenerative brain condition in which neurons in the memory and other cognitive areas of the brain lose function and die, resulting in progressive memory loss first, then difficulties learning and communicating, and, eventually, failing basic functions like breathing. In healthy neurons, enzymes help process a protein called amyloid precursor protein into fragments which help with normal cell function. In Alzheimer's, abnormal enzymatic processing produces fragments that include a sticky peptide called beta amyloid. Beta amyloid accumulates in the extracellular space, forming clumps called amyloid plaques. These clumps block the electrical and chemical connections between neurons. Inside healthy neurons, microtubules and tau proteins form an orderly structure that carries ions and nutrients within the cell. In Alzheimer's, chemical changes inside the neurons damage tau, twisting microtubules abnormally into neurofibrillary tangles, which disrupts ion and nutrient delivery within the cell. As the plaques and tangles multiply throughout brain tissue, neural connections diminish, and the malnourished cells lose function, resulting in widespread neural death, reduced brain mass, and severe cognitive and functional impairment. There is no cure for Alzheimer's, but current treatments include cholinesterase inhibitors, which delay the breakdown of acetylcholine, a neurotransmitter important for memory and learning, and antiglutamatergic medications, which regulate the activity of glutamate, another neurotransmitter essential for memory and learning, by blocking excessive glutamate binding to neurons, thus preventing neuronal dysfunction and death. ♪ [music] ♪
"Our practice involves medical negligence cases exclusively. We have six
attorneys and one physician on staff. We have used Medical Legal Art's
staff for every one of our cases over the past 12 years and have found their
services to be extraordinary. The transformation of medical records into
powerful graphic images has without fail been handled expertly,
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They are the best!"
Chris Otorowski
Morrow and Otorowski
Bainbridge Island, Washington
www.medilaw.com
"I have a medical illustration created by Medical Legal Art at the beginning
of every case to tell the client's story, usually before I depose the
defendant doctor. The work product and cost-efficiency are outstanding. It
is a situation where, as a trial lawyer, I don't leave home without it."
Rockne Onstad
Attorney at Law
Austin, TX
"We are extremely pleased with the quality of the medical exhibits and the
timely manner in which they were provided. I will certainly recommend
your company to my business associates who could benefit from your services.
Please tell Brian Wilson [Director of Content Development, Senior Medical
Illustrator] that he did an exceptional job on these exhibits."
K. Henderson
Dunaway and Associates
Anderson, SC
"I thought you might want to know that after we sent a copy of your
illustration to the defendants, with a copy to
the insurance company, they increased their offer by an additional million
dollars and the case was settled for $1,900,000.00.
I appreciate your help!"
O. Fayrell Furr, Jr.
Furr, Henshaw & Ohanesian
Myrtle Beach, SC
www.scmedicalmalpractice.com
Medical Legal Art creates medical demonstrative evidence (medical
illustrations, drawings, pictures, graphics, charts, medical animations,
anatomical models, and interactive presentations) for use during legal
proceedings, including research, demand letters, client conferences,
depositions, arbitrations, mediations, settlement conferences, mock jury
trials and for use in the courtroom. We do not provide legal or medical
advice. If you have legal questions, you should find a lawyer with whom you
can discuss your case issues. If you have medical questions, you should seek the advice of a healthcare provider.